Many Neglected Tropical Diseases May Have Originated in the Paleolithic or Before: New Insights from Genetics
نویسندگان
چکیده
The standard view of modern human infectious diseases is that many of them arose during the Neolithic when animals were first domesticated, or afterwards. Here we review recent genetic and molecular clock estimates that point to a much older Paleolithic origin (2.5 million years ago to 10,000 years ago) of some of these diseases. During part of this ancient period our early human ancestors were still isolated in Africa. We also discuss the need for investigations of the origin of these diseases in African primates and other animals that have been the original source of many neglected tropical diseases.
منابع مشابه
Is Really Weather or Tropical Conditions Affects an Outbreak of COVID-19: A Brief Report
Corona viruses are large group of viruses that can cause sickness ranging from normal flu to severe respiratory diseases. The new novel corona virus (nCOV-19) or COVID-19 is a new kind of pandemic virus that did not identified before in humans. Global nations have heightened their surveillance in the quick diagnosis of potential cases across the COVID-19. After it had originated in China more c...
متن کاملOrphan drug legislation: lessons for neglected tropical diseases.
In the last 20 years, orphan drug legislation (ODL) has been adopted in several countries around the world (USA, Japan, Australia, and the European Union) and has successfully promoted R&D investments to develop new pharmaceutical products for the treatment of rare diseases. Without these incentives, many life-saving new drugs would have not been developed and produced. For economic reasons, th...
متن کاملInm-8: Assisted Reproductive Technologies and Genetics
Genetic causes have a considerable involvement in infertility. Well-known examples are some chromosomal translocations or sex-chromosomal abnormalities and Y-chromosome deletions. The most common chromosomal aberrations associated especially with severe oligo- and azoospermia are sex chromosome aneuploidies and chromosomal translocations. Consequently, occurrence of aneuploid embryos will lower...
متن کاملRoutine Vaccination for Travelers from Emerging Countries: Epidemiological Profile of a Public Travel Medicine Clinic in Sao Paulo/Brazil
Introduction: Emerging countries have increased their presence in international travel (46.8% of travels). Pre- and post-travel consultations may provide insights about travelers’ health. Methods: A retrospective descriptive analysis of the medical data of all travelers assisted at Ambulatório dos Viajantes, a free public health clinic for travelers in Sã...
متن کاملExplaining the Presence of Narrow-faced Bladelet Cores in Izeh Chipped Stone Assemblages and its relation to Population/Idea Movements in Late Pleistocene
Abstract: Several models of population/culture movements have been proposed based on bladelet production in Late Pleistocene of Eurasia. Narrow-faced bladelet/microblade cores, also known as "wedge shaped" cores in Central Asia and Far East studies, have been considered as a component of an inter-continent migration of people and idea which originated in Sibero-Mongolian region Upper Paleolithi...
متن کامل